Dr Simon Jones and Ashleigh Evans are starting a collaborative drug discovery project with Retrogenix to identify the receptor for a key adipokine that they have shown mediates the production of catabolic proteases and pro-inflammatory cytokines in articular cartilage. Following receptor identification, the project will then validate its functional role in osteoarthritis. Retrogenix use a novel cell microarray platform specifically designed for drug target identification and receptor deorphanisation.